Meta-analysis of comparative efficacy of increasing dose of Atorvastatin versus Rosuvastatin versus Simvastatin on lowering levels of atherogenic lipids (from VOYAGER). 2008 Dec;15(6):314-23. doi: 10.5551/jat.e567. 2020 Mar;35(2):342-350. doi: 10.3904/kjim.2018.272. Changes in lipid levels and attainment rates of goal LDL cholesterol levels were estimated after accounting for baseline covariates using regression techniques. eAdjusted for age, sex, baseline laboratory test values, duration of therapy, and National Cholesterol Education Program risk status. [4] published additional therapeutic options and more aggressive LDL cholesterol goals for patients with multiple cardiovascular risks. 2003 Dec 1;4:18. doi: 10.1186/1471-2296-4-18. To comment please, Comments on Medscape are moderated and should be professional in tone and on topic. Korean J Intern Med. They also helps raise \"good\" cholesterol (HDL) in the blood. [12,13,14,15,16] When studied in a usual care setting or routine clinical practice setting, the effectiveness of statin therapy has been less than that observed in controlled, clinical trials. Additionally, the rosuvastatin group of patients, who were treated with half the dose of atorvastatin, achieved a significantly greater reduction in LDL-C levels (WMD = -3.57; 95% CI: -5.40--1.74 mg/dl, p < 0.001). Trial registration: Since cholesterol synthesis peaks between … Bae HJ, Cho YK, Park HS, Yoon HJ, Kim H, Han S, Hur SH, Kim YN, Kim KB, Ryu JK, Nah DY, Nam CW. The mechanism of action of both atorvastatin and rosuvastatin (called statins) is identical. Please confirm that you would like to log out of Medscape. Please enable it to take advantage of the complete set of features! Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials. 2018 Oct 22;2018:8380192. doi: 10.1155/2018/8380192. You must declare any conflicts of interest related to your comments and responses. Purpose: The effectiveness of rosuvastatin versus atorvastatin in reducing lipid levels and achieving low-density-lipoprotein (LDL) cholesterol goals in patients treated in a usual care setting was studied. There were no significant differences between the 2 groups in the effect on non-high-density lipoprotein cholesterol (non-HDL-C) and HbA1c at 12 months. bIndependent sample t test used for comparison of means. This website also contains material copyrighted by 3rd parties. Little is known about the differences between standard-dose statins effects on glucose level and lipids in Japanese patients with diabetes mellitus (DM). Am J Cardiol. Nicholls SJ, Brandrup-Wognsen G, Palmer M, Barter PJ. Burnout Might Really Be Depression; How Do Doctors Cope? Clipboard, Search History, and several other advanced features are temporarily unavailable. Propensity-score matching on baseline characteristics was used to minimize selection bias between groups. Siddhesh Kamat, M.S., is Outcomes Research Manager; and Debra A. Wertz, Pharm.D., is Senior Clinical Analyst/Medical Writer, Health Outcomes Research, HealthCore. Int J Endocrinol. Rosuvastatin 5 mg and atorvastatin 10 mg have a similar lowering effect on non-HDL-C, but might be different in terms of adverse effect on glucose levels. filled statin prescriptions, Mean ± S.D. DCI = Deyo-Charlson comorbidity index; ATP III = Adult Treatment Panel III b p < 0.05 for comparison between drugs. And although rosuvastatin … [3] These guidelines are based on results from previous randomized clinical trials and include specific goals for LDL cholesterol. However the usual dose of atorvastatin is 10mg … LDL = low-density-lipoprotein; CHD = coronary heart disease; CVD = cardiovascular disease; DM = diabetes mellitus; ACS = acute coronary syndrome; MS = metabolic syndrome. Conclusions: Since LDL cholesterol is the primary target of therapy, ATP III identified three classes of cardiovascular risk (low, moderate, and high) that describe LDL cholesterol levels. 2010 Mar;25(1):27-35. doi: 10.3904/kjim.2010.25.1.27. Michael F. Bullano; Siddhesh Kamat; Debra A. Wertz; Gerald M. Borok; Sanjay K. Gandhi; Kenneth L. McDonough; Vincent J. Willey. Get the latest research from NIH: https://www.nih.gov/coronavirus. NIH 2010 Jan 1;105(1):69-76. doi: 10.1016/j.amjcard.2009.08.651. Malays Fam Physician. [17] This may be due to factors usually associated with controlled, clinical trials, such as more frequent lipid monitoring; greater awareness of diet, exercise, clinical team support, and treatment reinforcement resulting from study participation; appropriate dosage adjustments; and increased medication compliance due to the free study drug. Lipitor and Crestor are also used to reduce the risk of heart attacks, stroke, and arterial revascularization procedures in patients with multiple risk factors for heart disease. USA.gov. NLM d p < 0.05, compared with rosuvastatin. Conclusion: Patients treated in a usual care setting with rosuvastatin had significantly greater reductions in LDL cholesterol, non-HDL cholesterol, and total cholesterol levels compared with those receiving atorvastatin. cDifference between preindex and postindex LDL cholesterol. This site needs JavaScript to work properly. Superior benefit of aggressive lipid-lowering therapy for high- risk patients using statins: the SUBARU study--more hypercholesterolemic patients achieve Japan Atherosclerosis Society LDL-C goals with rosuvastatin therapy than with atorvastatin therapy. Comparative study of low doses of rosuvastatin and atorvastatin on lipid and glycemic control in patients with metabolic syndrome and hypercholesterolemia. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. However, physicians tended to switch to more intensive therapy for DM in the atorvastatin group. Usefulness of aggressive lipid-lowering therapy with rosuvastatin in hypercholesterolemic patients with concomitant type 2 diabetes. Attainment rates for NCEP LDL cholesterol goals were significantly higher in patients receiving rosuvastatin. eCollection 2017 Nov. Angelidi AM, Stambolliu E, Adamopoulou KI, Kousoulis AA. © 2007  American Society of Health-System Pharmacists, aATP III = Adult Treatment Panel III. Crestor comes in the forms of 5, 10, 20 and 40-milligram tablets, and Lipitor comes in the form of 10, 20, 40 and 80-milligram tablets. Coronary heart disease (CHD) is the most common cause of death in the United States, accounting for nearly 500,000 deaths annually and an estimated $142 billion in annual direct and indirect costs. All of these factors are unlikely to represent everyday clinical practice settings. Lipitor (atorvastatin) and Crestor (rosuvastatin) are HMG-CoA reductase inhibitors (“statin” drugs) that lower cholesterol levels in the blood. Will Biased Ligands Be the Opioids of the Future? Currently, the most commonly used agents for lowering LDL cholesterol levels are hydroxymethylglutarase-coenzyme A reductase inhibitors, or statins. Epub 2009 Oct 16. Results: A total of 453 patients met the study criteria. Epub 2016 Feb 18. Compare Crestor vs Rosuvastatin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. postindex concentration (mg/dL). Endocrine. You've successfully added to your alerts. Sunjaya AP, Sunjaya AF, Halim S, Ferdinal F. Int J Angiol. Systematic Review Using Data from 1.9 Million Patients. Korean J Intern Med. The mean dose of rosuvastatin was 11 mg compared with 15 mg for atorvastatin. 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