Safeguards Before Taking Zetia. BS. started zetia in January-no issues for a month-then the gas started -then explosive gas-running to bathroom 8-15 times a day not knowing what is was going to be. Is it harmful to switch abruptly to another cholesterol-lowering medicine such as simvastatin? I have problems taking statins. Side effects of Zetia include: diarrhea, back pain, stomach or abdominal pain, numbness or tingly feeling, tired feeling, headache, dizziness, depressed mood, These thought leaders suggest that doctors should stick with statin-type cholesterol-lowering drugs, which have a proven track record. I called my doctor, who told me to continue taking it, but if it’s not doing anything good for my high cholesterol, why bother? In the meantime, keep in mind that Zetia may cause muscle pain itself. A pharmacist told me that the FDA hasn’t recalled it, so it must be all right. What Are Side Effects of Zetia? Within the past few years, FDA has approved new drugs to lower cholesterol. He advised his colleagues not to prescribe Zetia except as a last resort. There should be no danger switching to simvastatin, since it has been shown to be effective at lowering cholesterol and reducing the risk of heart attacks in people with heart disease (Ursoniu et al, Pharmacological Research, online June 9, 2017). Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. It is Show 1031. A. Zetia (ezetimibe) and Vytorin (ezetimibe and simvastatin) lower cholesterol. I still have muscle pain, cramps and tingling in my legs and feet. In the wake of the ENHANCE study that produced such disappointing results with Vytorin, the American College of Cardiology convened an expert panel to advise their colleagues. But what about ezetimibe (Zetia)? I still have muscle pain, cramps and tingling in my legs and feet. But the new two-year trial of 720 patients sheds doubt on whether it makes any sense for people battling cholesterol to take Vytorin versus Zocor alone, experts said. Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches… Sometimes, however, doctors find it hard to resist reaching into their toolbox for the newest thing that might help. Zetia (ezetimibe) is a lipid-lowering compound used to treat high cholesterol. Although Zetia works differently from statin cholesterol-lowering drugs such as Lipitor or Zocor, it is absorbed into the bloodstream. You can learn more about these medications from our interview with Dr. Steve Nissen about the GAUSS-3 trial of evolocumab and ezetimibe in people who have muscle pain on statins. Zetia helps you reduce bad cholesterol which can assist in stopping serious problems such as heart attack and stroke. They found that when people dropped ezetimibe their cholesterol rose. Here are some of the other problems those taking Zetia have faced: allergic reactions including facial and throat swelling which may cause difficulty in breathing or swallowing. Can you shed any light on this? That increased their predicted risk of cardiovascular disease. Another reader wrote us shortly after learning of the results of a study that raised questions about ezetimibe: Q. Unfortunately, it didn’t reduce the risk of dying from cardiovascular causes. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. Evolocumab (Repatha) and alirocumab (Praluent) are PCSK9 inhibitors. My doctor put me on Zetia and insists it can’t cause muscle pain since it is not absorbed into the blood stream. Scientists compared the thickness of the lining of the carotid arteries in the neck between people put on Vytorin and those on simvastatin (Kastelein et al, New England Journal of Medicine, Apr. As it turns out, Zetia may cause muscle problems, too. Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide — for FREE! Learn about side effects, dosage, and more. They do not have data to show whether people who stopped taking Zetia had more heart attacks or strokes, so the jury is still out on that. He was not the only one to see ezetimibe in a less positive light. Zetia works by decreasing the absorption of cholesterol from the intestine. Muscle side effects seem to be less common with Zetia than with the statin drugs, but Zetia may cause muscle problems. My doctor put me on Zetia and insists it can’t cause muscle pain since it is not absorbed into the blood stream. The unresolved question is whether they prevent atherosclerosis, heart attacks and strokes. Can Zetia cause this? GAUSS-3 trial of evolocumab and ezetimibe. They lower cholesterol dramatically through a different mechanism from statins. My doctor tells me that until more is known, I should continue taking the prescribed medicine. She is a Fellow of the Society of Applied Anthropology. Probably the most troublesome side effect patients report on one of these drugs is muscle pain or weakness. We have written quite a bit about the side effects of statins such as atorvastatin (Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor). The investigators note that many people stopped taking Vytorin or Zetia after they learned about this trial. A. Consequently, we expect that other patients might end up taking them. That’s too bad, they say. 3, 2008). Terry is one of the country's leading authorities on the science behind folk remedies. Repatha has been shown to reduce the risk of heart attack and stroke (Sabatine et al, New England Journal of Medicine, May 4, 2017). A. Q. 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