Most reported clinical trials have been small and poorly designed, and in some studies, a number of different herbs were coadministered with rhubarb, making it difficult to evaluate which herb contributed to the outcomes. Evaluation of anti-inflammatory markers suggests that an anti-inflammatory action of rhubarb is responsible for the effect.18, In addition to the sennosides present in rhubarb extracts, which have been traditionally used as a laxative, emodin and other anthraquinones exert action on the GI tract. The first reported sighting of the plant in situ was in the mountains of Bulgaria. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. They have high levels of oxalic acid that can damage your kidneys and even lead to death if ingested in very high levels. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Colour It Green explains the easy process. Low molecular weight tannins, purified from rhubarb, produced an increase in glomerular filtration rate, decreased levels of uremic toxins, and increased blood flow to the kidneys.25, 29, 30, 31, 32, Use of rhubarb extract in patients with elevated serum creatinine has been reported to prevent progression of CRF. This information relates to an herbal, vitamin, mineral or other dietary supplement. Rhubarb-based interventions included Taohe chengqi, Xinglou chengqi, Dachengqi, modified chengqi, and Sanhua. Rhubarb extract has been evaluated in pregnancy-related hypertension at 0.75 g daily50; however, anthraquinones may have uterine-stimulant and genotoxic effects.51, 52, With long-term overuse, rhubarb may increase the toxic effects of cardiac glycosides. It closely resembles celery, after all, which … Emodin is metabolized in the large intestine by intestinal bacteria and converted to aglycone, which exerts various effects on absorption, secretion, and motility in the tract, and is also suggested to increase peristalsis without affecting the stomach or duodenum.12 It has been used in cases of GI bleeds to eliminate extravasated blood.12, 19, In a study among patients with septicemia, crude rhubarb extract powder 9 g daily was used to preserve GI function. An effect on antiarrhythmics is possible because of the loss of potassium. This is only a brief summary of general information about this product. Potassium deficiency can be increased by concurrent use of thiazide diuretics, corticosteroids, or licorice root. Rhubarb leaves are considered inedible due to their high concentration of oxalic acid.In fact, both the stalks and leaves contain oxalic acid, but the leaves have a much higher content. Use precautions when harvesting rhubarb by trimming the leaves from the stalks immediately, not using stalks from plants that have been "frost bitten", and washing the stalks before using them, and before preparing them for the freezer or for canning rhubarb.. Children should be taught to eat only the rhubarb stalks, (if they do not find the raw rhubarb too tart! Although this pesticide should not be used on edible crops, I thought I would still include this recipe since you can use your edible crops to help out the rest of your garden. No evidence of any difference in effectiveness was found in 1 randomized clinical trial (N = 45) for the treatment of primary dysmenorrhea with rhubarb (1,260 mg twice daily beginning 2 days before menstruation and continued for the first 3 days of menstruation × 3 cycles [2,520 mg/day]) compared to mefanamic acid (250 mg 3 times daily [750 mg/day]). Savor the Rhubarb has a tutorial on how to turn these leaves into garden decor. Get Crafty and Use Them to Make Stepping Stones, 20 Ways to Reuse Coffee Grounds, Tea Leaves, 20 Uses for Leftover Fruit and Vegetable Peels. Rhubarb extract 20 mg/kg daily administered for 6 weeks to patients undergoing radiation therapy for cancer resulted in a reduction in radiation-induced lung toxicity in a randomized clinical trial. The perennial herb has a conical rootstock, that is fleshy and yellow inside and produces large, cordate, 7-lobed leaves 30 to 46 cm long. Trials have been conducted comparing captopril and rhubarb. An anti-inflammatory action has also been suggested.22, Experiments in mice and rats receiving a cholesterol-enriched diet or with induced diabetic nephropathy/hyperlipidemia showed an improved lipid profile with rhubarb extract compared with control animals.23, 24, 25 Rabbits with induced atherosclerotic plaques and fed a high-cholesterol diet demonstrated a decrease in plaque rupture with either administration of rhubarb extract or simvastatin compared with control. Calcium oxalate crystals form and occlude the dentinal tubules responsible for sensitization.42, A Cochrane systematic review and meta-analysis of dietary supplements for dysmenorrhea identified only low or very low quality studies with very small sample sizes. The edible stalks are up to 45 cm long and 2.5 to 5 cm in diameter, and are used in pies, jams, jellies, sauces, and juices.1, 2, Medicinal rhubarb consists of the dried rhizome and root of R. officinale Baillon or R. palmatum, of related species/hybrids grown in China (Chinese rhubarb), or of Rheum emodi or Rheum webbianum native to India, Pakistan, or Nepal (Indian rhubarb).3, Rhubarb was first recorded and rated as one of the inferior remedies in the oldest Chinese herbal books, from 22 to 250 AD.4 In the 1780s, the active constituents responsible for the root's cathartic action and astringency were still unknown. This information should not be used to decide whether or not to take this product. Celebrate spring’s bounty with these 25 delicious rhubarb-studded recipes. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Rhubarb leaves can grow to be very big and when used as the template for a cement casting, they make beautiful leaf-shaped stepping stones. Rhubarb is derived from several Rheum species. Lipid profiles were improved in the two experimental arms.22, Treating hypercholesterolemia in men with rhubarb stalk fiber for 4 weeks lowered serum total cholesterol and low-density lipoproteins (LDL), while high-density lipoproteins remained unchanged.26 In 103 patients with atherosclerosis randomized to receive the extract for 6 months, rhubarb extract improved the lipid profile in patients with chronic renal failure (CRF) compared with control.25 Individuals taking rhubarb reported decreased LDL compared with those taking placebo and compared with the pretreatment levels.27, Large, randomized clinical trials are lacking. A small amount of rhubarb may have adhered to the wall of the tracheobronchial tree, producing a localized area of oxalosis with accompanying necrosis.54 Consumption of rhubarb in patients with renal stones is not advised because of the oxalate content.13, The leaf blades, but not the stalks, of rhubarb contain enough oxalic acid to cause poisoning.2 Acute renal failure has been associated with long-term anthraquinone use.28, Emodin was mutagenic in several Salmonella typhimurium strains, and has been demonstrated to be phototoxic in vitro.12. The free anthraquinones—rhein, emodin, physcion, and chrysophamol—are present in nearly all species.7 Stilbene glycosides, including rhaponticin and the metabolite rhapontigenin, have been identified in the root.4, 7, 8, 9 Tannins, sennosides, catechins, gallic acid, and cinnaminic acid have been identified.7 Lindleyin, a phytochemical with estrogenic activity, has also been described.10 Rhubarb is also a dietary source of resveratrol.57, Oxalic acid is present in the leaf blades, as well as 2-methylbutanol and 4-methylhexanol.2, 11. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. 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