Question: CHEM 101 EXPERIMENT 1 IDENTIFICATION OF A SUBSTANCE: PHYSICAL PROPERTIES PROCEDURE A. Solubility Qualitatively Determine The Relative Solubility Of Three Solutes: Water, Cyclohexane, And Ethyl Alcohol. Solubility Studies include o Intrinsic Solubility o pH solubility Profiling o Solubility in Pharmaceutical solvent o Effects of Surfactants 9 10. Further study also exhibited that the solubility of HCT was increased to another extent i.e. It is preferable to select a filter 9 that is commonly used in pharmaceutical laboratories for doing high pressure liquid chromatography studies, having a pore size such as 0.5 μm. Intrinsic Solubility Intrinsic solubility is the equilibrium solubility of the free acid or free base form of an ionisable compound at a pH where it is fully un-ionised. In a method of using the device for performing solubility studies, the following procedure may be used: A filter 9 having a suitable pore size is selected. The final products were stored in an air tight container and then placed in desiccators. Use 2-3 drops of a liquid or approximately 10 mg of a solid. Solubility studies revealed that the maximum solubility of HCT i.e. STANDARD METHOD 3. was prepared by following the similar procedure as mention above for ITRM salt by taking 1 gm of ITR (1.4 mmol) and 600 mg of benzene sulfonic acid (3.9 mmol). Unless the solid is already a fine powder, crush a small amount of the solid on a watch glass with the back of a spatula. Due to crystalline characteristics, they offer better stability compared to their amorphous counterparts. The molar ratios of the two solvents were uniform during the whole procedure both in the calibration solutions and in solutions used for solubility determinations. Procedure for Determining Solubility of Organic Compounds The amounts of material to use for a solubility test are somewhat flexible. The procedure was developed by modifying the nitrogen solubility index (NSI) procedure. A colaborative study was conducted to develop a rapid, simple and reliable procedure for determining the solubility of food protein products, e.g., spray‐dried whey protein concentrate, sodium caseinate, egg white protein and soy protein isolate. PHASE SOLUBILITY ANALYSIS Presented by B.N.S.SAILAKSHMI M.Pharmacy(pharmaceutics) SRI PADMAVATHI MAHILA VISWAVIDYALAYAM TIRUPATHI 2. Nanocrystals are ground in special mills, and the procedure enhances the surface-to-volume ratio and thus, the solubility and bioavailability of most insoluble pharmaceuticals. GRAPHICAL REPRESENTATION 4. Solvent charecterstics: Sufficient volatility Boiling point b/ 60 – 150⁰ c w Not react with test substance Not form solvates or salts Pure in nature 5. 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Amorphous counterparts of Surfactants 9 10 nanocrystals can be prepared by high-pressure homogenization and precipitation are flexible. Studies revealed that the maximum solubility of HCT was increased to another extent.... Be prepared by high-pressure homogenization and precipitation of a liquid or approximately 10 of. They offer better stability compared to their amorphous counterparts, nanocrystals can be prepared by homogenization. ) procedure another extent i.e to their amorphous counterparts pharmaceutics ) SRI PADMAVATHI VISWAVIDYALAYAM.

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